Functional Effects of Cromakalim on Aortic Tissue in STZ-Diabetic Rats: Impact of Insulin Treatment

These findings indicate that potassium channel activity and vascular vasodilation ability decrease in the aortas of streptozotocin-diabetic rats depending on the duration of diabetes. In contrast, potassium channel activity and vascular vasodilation ability return to normal with insulin treatment in 14-week streptozotocin-diabetic aortas.

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Publication Details

Journal
Current Drug Research Reviews
Published
2025-07-30
DOI
https://doi.org/10.2174/0125899775374270250714222602
Primary Topic
Nitric Oxide and Endothelin Effects
Type
article
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article

Functional Effects of Cromakalim on Aortic Tissue in STZ-Diabetic Rats: Impact of Insulin Treatment

Fuat Nihat Özaydın
Current Drug Research Reviews
Nitric Oxide and Endothelin Effects
article

Functional Effects of Cromakalim on Aortic Tissue in STZ-Diabetic Rats: Impact of Insulin Treatment

Fuat Nihat Özaydın
article en

Abstract

These findings indicate that potassium channel activity and vascular vasodilation ability decrease in the aortas of streptozotocin-diabetic rats depending on the duration of diabetes. In contrast, potassium channel activity and vascular vasodilation ability return to normal with insulin treatment in 14-week streptozotocin-diabetic aortas.

Current Drug Research ReviewsVol. 17
Istanbul University (TR)
Openalex Percentile: Top 75%
Nitric Oxide and Endothelin Effects
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Functional Effects of Cromakalim on Aortic Tissue in STZ-Diabetic Rats: Impact of Insulin Treatment — Fuat Nihat Özaydın · Current Drug Research Reviews (2025) | TGRS Research Map | TGRS