Integrative analysis of lactylation related genes in prostate cancer: unveiling heterogeneity through single-cell RNA-seq, bulk RNA-seq and machine learning
This study offers a comprehensive analysis of lactylation in prostate cancer, identifying potential prognostic biomarkers. The proposed prognostic signature provides a novel approach to personalized treatment strategies, deepening our understanding of the molecular mechanisms driving prostate cancer and offering a tool for predicting therapeutic responses and clinical outcomes.
Authors
- Gonghui Li (ORCID: https://orcid.org/0000-0001-9845-7241)
- Huailan Wang
- Chenhao Zhou (ORCID: https://orcid.org/0000-0002-4800-3249)
- Lifeng Ding (ORCID: https://orcid.org/0000-0002-1145-9584)
- Lei Gao (ORCID: https://orcid.org/0000-0002-3897-6362)
Institutions
- Sir Run Run Shaw Hospital (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-08-04
- DOI
- https://doi.org/10.3389/fphar.2025.1634985
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00