Integrative analysis of lactylation related genes in prostate cancer: unveiling heterogeneity through single-cell RNA-seq, bulk RNA-seq and machine learning

This study offers a comprehensive analysis of lactylation in prostate cancer, identifying potential prognostic biomarkers. The proposed prognostic signature provides a novel approach to personalized treatment strategies, deepening our understanding of the molecular mechanisms driving prostate cancer and offering a tool for predicting therapeutic responses and clinical outcomes.

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Publication Details

Journal
Frontiers in Pharmacology
Published
2025-08-04
DOI
https://doi.org/10.3389/fphar.2025.1634985
Primary Topic
Ferroptosis and cancer prognosis
Type
article
Field-Weighted Citation Impact
0.00
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article

Integrative analysis of lactylation related genes in prostate cancer: unveiling heterogeneity through single-cell RNA-seq, bulk RNA-seq and machine learning

Gonghui Li, Huailan Wang, Chenhao Zhou, Lifeng Ding et al.
Frontiers in Pharmacology
Ferroptosis and cancer prognosis
article

Integrative analysis of lactylation related genes in prostate cancer: unveiling heterogeneity through single-cell RNA-seq, bulk RNA-seq and machine learning

Gonghui Li, Huailan Wang, Chenhao Zhou, Lifeng Ding, Lei Gao
article en

Abstract

This study offers a comprehensive analysis of lactylation in prostate cancer, identifying potential prognostic biomarkers. The proposed prognostic signature provides a novel approach to personalized treatment strategies, deepening our understanding of the molecular mechanisms driving prostate cancer and offering a tool for predicting therapeutic responses and clinical outcomes.

Frontiers in PharmacologyVol. 16
Sir Run Run Shaw Hospital (CN), Zhejiang University (CN)
Good health and well-being
Openalex Percentile: Top 70%
Ferroptosis and cancer prognosis
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