Predict potential pharmacological mechanisms of Ling-gui-Zhu-gan Decoction in treating unstable angina pectoris using liquid chromatography-mass spectrometry and network pharmacology
The analytical method established in this study effectively delineates the chemical profile and index component transfer dynamics of LGZGD preparation intermediates, providing essential data for the development of both liquid and solid dosage forms. The constructed "medicine-component-target-pathway-disease" network preliminarily reveals the multi-component, multi-target, and multi-pathway mechanisms by which LGZGD may exert therapeutic effects on UA. This work provides a scientific foundation for its clinical application, supporting rational drug use and formulation development.
Authors
- Li Han (ORCID: https://orcid.org/0000-0002-1982-8532)
- Fengyu Dong (ORCID: https://orcid.org/0000-0002-5906-3319)
- Haiying Huang (ORCID: https://orcid.org/0000-0003-2968-1869)
- Panpan Zhang (ORCID: https://orcid.org/0000-0002-9319-809X)
- Jing Yao (ORCID: https://orcid.org/0000-0001-7854-6140)
- Ruixin Liu (ORCID: https://orcid.org/0000-0001-5126-1532)
- Xiaopeng Li (ORCID: https://orcid.org/0009-0008-8695-5591)
- Xue Tan
Institutions
- Henan University of Traditional Chinese Medicine (CN)
- Chinese Pharmaceutical Association (CN)
- First Affiliated Hospital of Henan University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Chemistry
- Published
- 2025-08-04
- DOI
- https://doi.org/10.3389/fchem.2025.1649538
- Citations
- 1
- Primary Topic
- Pharmacological Effects of Natural Compounds
- Type
- article
- Field-Weighted Citation Impact
- 1.56