Sub-inhibitory concentrations of oxacillin modulate biogenesis and function of extracellular vesicles secreted by oxacillin-sensitive methicillin-resistant Staphylococcus aureus
Exposure to sub-inhibitory concentrations of oxacillin significantly altered the secretion and composition of EVs, highlighting a novel relationship between antimicrobial exposure, exosome biogenesis, and OS-MRSA pathogenicity. These findings provide new insights into how β-lactam antibiotics influence host-pathogen interactions by modulating the secretion of bacterial vesicles.
Authors
- Binxin Guo
- Junrui Wang (ORCID: https://orcid.org/0000-0001-7533-0723)
- Mingju Hao (ORCID: https://orcid.org/0000-0002-2714-3998)
- Zhaoxia Ran
Institutions
- Ningxia Medical University (CN)
- Ningxia Medical University General Hospital (CN)
- Inner Mongolia Medical University (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-08-04
- DOI
- https://doi.org/10.3389/fmicb.2025.1616536
- Citations
- 3
- Primary Topic
- Bacterial Infections and Vaccines
- Type
- article
- Field-Weighted Citation Impact
- 3.55
Funders
- National Natural Science Foundation of China