Expression and clinical significance of Klotho protein in serum, umbilical cord blood, and placenta of pregnant women with intrauterine growth restriction
Reduced Klotho expression in IUGR cases, along with changes in GH and IGF-1, suggests disruptions in metabolic processes affecting fetal growth and development. These findings suggest a potential involvement of Klotho in placental changes and fetal development, warranting further mechanistic studies.
Authors
- Jiajia Shen (ORCID: https://orcid.org/0000-0002-9186-321X)
- Guixiang Zeng
- Jie Lian (ORCID: https://orcid.org/0000-0003-3538-7746)
Institutions
- Guangxi Maternal and Child Health Hospital (CN)
- Children's Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Frontiers in Pediatrics
- Published
- 2025-08-04
- DOI
- https://doi.org/10.3389/fped.2025.1611877
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Key Research and Development Program of China