Spatial transcriptomics reveals Inhba/Smad2/E2f4 axis in Lrp2high thecal cell proliferation in androgen-induced PCOS mice
The Inhba/Smad2/E2f4 axis contributes to thecal cell hyperplasia and androgen excess in PCOS, and may serve as a mechanistic entry point for further investigation into the regulation of TCs proliferation in this disorder.
Authors
- Xiaona Tian (ORCID: https://orcid.org/0009-0008-2410-9509)
- Xiaoyan You (ORCID: https://orcid.org/0000-0002-4801-874X)
- Jianping Ye (ORCID: https://orcid.org/0000-0003-3875-365X)
- Longzhi Mei (ORCID: https://orcid.org/0000-0002-0274-6231)
- Man Luo (ORCID: https://orcid.org/0000-0002-9975-2434)
- Dongmei Zhang (ORCID: https://orcid.org/0000-0001-8586-4921)
- Ao Li (ORCID: https://orcid.org/0000-0002-7130-2386)
- Xiaofeng Yang (ORCID: https://orcid.org/0000-0001-9574-0826)
- Xiao Cheng (ORCID: https://orcid.org/0000-0001-9825-2107)
- Mengsi Zhou
- Guomei Zhang (ORCID: https://orcid.org/0009-0000-6936-4484)
- Wenzhi Liu (ORCID: https://orcid.org/0000-0002-6832-4576)
- Haoran Li (ORCID: https://orcid.org/0000-0002-8485-9378)
Institutions
- Zhengzhou University (CN)
- Research Institute for Farm Animal Biology (FBN) (DE)
- Zhengzhou Central Hospital (CN)
- University of Rostock (DE)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-08-04
- DOI
- https://doi.org/10.3389/fcell.2025.1633254
- Primary Topic
- Reproductive Biology and Fertility
- Type
- article
- Field-Weighted Citation Impact
- 0.00