Celecoxib disrupts temporal coordination of TGF-β/α-SMA signaling in skeletal muscle repair: a time-dependent study of fibrosis and inflammation

Celecoxib mitigates early-phase inflammation, its prolonged use may compromise late-stage tissue maturation. These findings advocate for time-restricted administration of celecoxib in muscle injury therapy, emphasizing the need to balance acute symptom management with long-term functional recovery.