Cu(OAc)<sub>2</sub>/TBPB-Mediated Cross-Dehydrogenative Coupling Reactions of Di/Trifluoromethylated <i>N</i>-Acylhydrazones with Diarylphosphine Oxides
A cross-dehydrogenative coupling reaction of fluoroalkylated <i>N</i>-acylhydrazones with diarylphosphine oxides is reported, which offers an effective route for the synthesis of phosphorylated di/trifluoromethylated N-acylhydrazones in moderate to excellent yields in the presence of Cu(OAc)<sub>2</sub>/TBPB. The method features a broad substrate scope. Mechanistic studies indicate that the reaction involves a radical CDC process between <i>N</i>-acylhydrazones and diarylphosphine oxides.
Authors
- Yulai Hu (ORCID: https://orcid.org/0000-0002-9630-4150)
- Gaowang Yang (ORCID: https://orcid.org/0009-0005-5146-2082)
- Ke‐Hu Wang (ORCID: https://orcid.org/0000-0001-8246-3559)
- Danfeng Huang (ORCID: https://orcid.org/0000-0002-5848-1164)
- Ying Fan (ORCID: https://orcid.org/0000-0002-2288-9248)
- Peng Jin (ORCID: https://orcid.org/0000-0001-6925-9094)
- Ruikang K. Wang (ORCID: https://orcid.org/0000-0001-5169-8822)
- Zuyu Bai
Institutions
- State Key Laboratory of Applied Organic Chemistry
- Northwest Normal University (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-08-04
- DOI
- https://doi.org/10.1021/acs.joc.5c00772
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China