Advantages and Challenges of Automated Insulin Delivery Use in Pregnancy: Physiology Considerations

Pregnancy is a unique stage of life characterized by continuous maternal physiologic adaptations from conception to postpartum. Understanding the dynamic metabolic requirements of pregnancy can inform the effective use of current automated insulin delivery (AID) tools and aid in developing future diabetes technology to support diabetes management in this critical life period. In this review, we detail physiologic changes affecting early pregnancy, late pregnancy, intrapartum, and postpartum and discuss implications for using and designing AID systems.