Association of plastic-associated chemicals with Alzheimer's disease amyloid-β and cognitive status
Alzheimer's disease (AD) is characterized by amyloid-β (Aβ) for ∼20 years prior to dementia onset. Phthalates, routinely added to plastics to increase flexibility, and bisphenol monomers, have been shown to interfere with neural activity/brain function. Phthalate and bisphenol exposure did not show association of individual urinary biomarkers with Aβ or clinical phenotype (mild cognitive impairment (MCI)/AD). Assessing biomarkers in quartiles, low mono(2-ethylhexyl) phthalate (MEHP), but not other biomarkers of di(2-ethylhexyl) phthalate (DEHP), was associated with Aβ+ and with having MCI/AD (q < 0.05), while high Bisphenol S (BPS) was associated with Aβ+ (q < 0.05). Mixture analysis shows significant association with MCI/AD but not Aβ.
Authors
- James D. Doecke (ORCID: https://orcid.org/0000-0003-2863-0293)
- Jürgen Fripp
- Chang He (ORCID: https://orcid.org/0000-0003-2345-5940)
- Rodrigo Cánovas (ORCID: https://orcid.org/0000-0003-3987-8884)
- Colin L. Masters (ORCID: https://orcid.org/0000-0003-3072-7940)
- Sarah A. Dunlop (ORCID: https://orcid.org/0000-0002-1306-3962)
- Ayomi Jayarathne (ORCID: https://orcid.org/0000-0002-9686-3630)
- Christopher Fowler (ORCID: https://orcid.org/0000-0003-1397-0359)
- Ahmed Elagali (ORCID: https://orcid.org/0000-0002-8093-4107)
- Jochen F. Mueller (ORCID: https://orcid.org/0000-0002-0000-1973)
- Xianyu Wang (ORCID: https://orcid.org/0000-0002-5917-3366)
Institutions
- Commonwealth Scientific and Industrial Research Organisation (AU)
- Guangdong University of Technology (CN)
- The University of Queensland (AU)
- The University of Melbourne (AU)
- The University of Western Australia (AU)
- Florey Institute of Neuroscience and Mental Health (AU)
- Metro South Health (AU)
- Key Laboratory of Guangdong Province (CN)
- Walk Free Foundation (AU)
- Australian e-Health Research Centre (AU)
- Minderoo Foundation
Publication Details
- Journal
- Journal of Alzheimer s Disease
- Published
- 2025-08-03
- DOI
- https://doi.org/10.1177/13872877251364559
- Citations
- 3
- Primary Topic
- Effects and risks of endocrine disrupting chemicals
- Type
- article
- Field-Weighted Citation Impact
- 3.60