Study of Immunohistochemical Expression of p53 and Ki-67 in Oral Squamous Cell Carcinoma

Objective: “Study of Immunohistochemical Expression of p53 and Ki-67 in Oral Squamous Cell Carcinoma” Methods: The descriptive analysis, which was based in a hospital, comprised 60 cases of oral squamous cell carcinoma (OSCC). Cases presented at Muzaffarnagar Medical College, Pathology department. Immunohistochemically, p53 and Ki-67 expression were assessed and correlated with clinicopathological characteristics. Results: The Majority of cases having OSCC were in fifth and sixth decades. ‘The tongue is the most common site for OSCC.’ Tobacco use was present in 68.3% of patients. Most OSCC instances were moderately differentiated. p53 and Ki-67 expression were substantially higher in poorly differentiated patients. No significant correlation was seen between age, gender, or histological grade and 56.7% positive p53 expression. A strong correlation existed between age, histological grade, and Ki-67 expression. Conclusion: ‘The study highlights the importance of understanding oral squamous cell carcinoma patients' habits and characteristics for improvement of prognosis as well as the treatment options. These markers are recommended for assessing OSCC aggressiveness and progression, but further research is needed to understand their roles in treatment outcomes by incorporating a broader panel of markers.’