Characterization of bronchus-associated lymphoid tissue induced by co-exposure to Asian sand dust and ovalbumin: a study using 3D serial section imaging
B cell clusters including iBALTs are induced by ASD; this process is enhanced by OVA, in which T<sub>fh</sub> cells were suggested to play important roles. Characterization of the OVA+ASD-induced B cell clusters proved that the SS3D technique is useful for the analysis of mouse disease models. The results also emphasize the need for medical countermeasures for patients with allergic diseases living in areas with ASD contamination.
Authors
- Manabu Hayatsu
- Yoshikazu Mikami (ORCID: https://orcid.org/0000-0001-9263-3937)
- Hiromasa Tsuda (ORCID: https://orcid.org/0000-0002-2047-2262)
- Hirohisa Takano
- Taku Toriumi (ORCID: https://orcid.org/0009-0004-0275-425X)
- Akiko Honda (ORCID: https://orcid.org/0000-0002-7358-4372)
- Etsushi Kuroda (ORCID: https://orcid.org/0000-0002-7198-2190)
- Takamichi Ichinose (ORCID: https://orcid.org/0000-0002-5427-8070)
- Yusuke Mizutani (ORCID: https://orcid.org/0000-0002-3555-9889)
Institutions
- Nihon University (JP)
- Hyogo Medical University (JP)
- Hokkaido University of Education (JP)
- Health Sciences University of Hokkaido (JP)
- Hokkaido University (JP)
- Kyoto University (JP)
- Nippon Dental University (JP)
- International Institute for Advanced Studies (JP)
- Kyoto International University (JP)
- Kyoto University of Foreign Studies (JP)
- Niigata University (JP)
- Kyoto University of Advanced Science (JP)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-08-04
- DOI
- https://doi.org/10.3389/fimmu.2025.1578255
- Citations
- 1
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Japan Society for the Promotion of Science
- Japan Science and Technology Agency