The C-type lectin receptor Dcir (Clec4a2) restrains Aspergillus fumigatus elimination by limiting the degranulatory activity of neutrophils
The results indicate a potential association between Dcir and downregulation of signalling pathways associated with neutrophil exocytosis. Thus, Dcir is a potential novel fungal sensor that, unlike other CLR family members, primarily fine-tunes host effector responses.
Authors
- Shinobu Saijo (ORCID: https://orcid.org/0000-0002-3802-8821)
- Shota Torigoe (ORCID: https://orcid.org/0000-0002-4884-3686)
- Fábio Seiti Yamada Yoshikawa (ORCID: https://orcid.org/0000-0002-6112-7107)
- Ryuichi Yabe
- Sho Yamasaki (ORCID: https://orcid.org/0000-0002-5184-6917)
Institutions
- Chiba University (JP)
- National Institute of Infectious Diseases (JP)
- Tokyo Metropolitan Institute of Medical Science (JP)
- Osaka International Cancer Institute (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-08-04
- DOI
- https://doi.org/10.3389/fimmu.2025.1639400
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chiba University
- Japan Society for the Promotion of Science