Screening antiseizure medications to break the cycle between neuronal hyperexcitability and Alzheimer's disease

Epilepsy is commonly comorbid with Alzheimer's disease and is now well established to accelerate disease course. In the present study, Knox and colleagues evaluated the efficacy of several antiseizure medications (ASMs) in mitigating seizure induction in two aged Alzheimer's disease mouse models with distinct etiologies. They found differential responses to seizure induction and ASM treatment across sexes and models. These results reveal a complex interplay between sex, Alzheimer's disease risk genes, and neuronal hyperexcitability that suggest a tailored approach to seizure control may maximize therapeutic benefit in Alzheimer's disease.