A proof-of-concept study of personalized dosimetry for targeted radioligand therapy using pre-treatment diagnostic dynamic PET/CT and Monte Carlo simulation

We developed a framework for personalized TRT dose calculations using pre-treatment diagnostic PET/CT scans, eliminating the need for post-treatment SPECT/CT scans via the LDV-based method. This approach addresses variability in tumor and organ-at-risk doses from one-size-fits-all radioligand dosing, enabling optimized pre-treatment planning and integration with external beam radiation therapy (EBRT) or brachytherapy, if indicated, for precise and effective therapy. This method shows promise but requires further validation through larger studies and direct comparison with post-treatment dosimetry to confirm its accuracy.