Combined inhibition of dopamine D1/D2 receptors induces cognitive and emotional dysfunction through oxidative stress and dopaminergic neuron damage
This is the first study to demonstrate that co-DR1/2I triggers cognitive and emotional dysfunction by exacerbating oxidative stress and dopaminergic neuronal damage, thereby advancing our understanding of the neurotoxic mechanisms of dopamine receptor antagonists. Future studies are needed to explore targeted antioxidant therapies and receptor-selective modulation strategies to reduce the side effects.
Authors
- Yao Zhuang
- Yuheng Zhang (ORCID: https://orcid.org/0009-0009-2457-0976)
- Xue Li (ORCID: https://orcid.org/0000-0001-7101-1506)
- Li Liu (ORCID: https://orcid.org/0000-0002-8745-8465)
- Xuan Liu (ORCID: https://orcid.org/0000-0001-5629-9986)
- Jing Sun (ORCID: https://orcid.org/0000-0002-6459-1255)
- Xin Chen (ORCID: https://orcid.org/0009-0000-2718-7504)
- Kongxi Fan
Institutions
- Changzhou University (CN)
Publication Details
- Journal
- Frontiers in Behavioral Neuroscience
- Published
- 2025-08-04
- DOI
- https://doi.org/10.3389/fnbeh.2025.1621017
- Citations
- 1
- Primary Topic
- Neurotransmitter Receptor Influence on Behavior
- Type
- article
- Field-Weighted Citation Impact
- 0.91