Repurposed clindamycin suppresses pyroptosis in tumor-associated macrophages through Inhibition of caspase-1
Our computational workflow for drug repurposing identified clindamycin as an efficacious inhibitor of caspase-1 that suppresses inflammasome activity and pyroptosis in vitro in TAMs.
Authors
- Xin Lai (ORCID: https://orcid.org/0000-0002-5172-3968)
- Krishna P. Singh (ORCID: https://orcid.org/0009-0004-8789-615X)
- Katrin Bitterer
- Adrian Weich (ORCID: https://orcid.org/0000-0002-2803-2034)
- Cindy Flamann
- Olaf Wolkenhauer (ORCID: https://orcid.org/0000-0001-6105-2937)
- Johannes Berges (ORCID: https://orcid.org/0000-0002-2613-0319)
- Shailendra K. Gupta (ORCID: https://orcid.org/0000-0002-3470-3260)
- Carola Berking (ORCID: https://orcid.org/0000-0003-0229-8931)
- Heiko Bruns (ORCID: https://orcid.org/0000-0002-8463-6924)
- Gerhard Krönke (ORCID: https://orcid.org/0000-0002-7566-4325)
- Julio Vera (ORCID: https://orcid.org/0000-0002-3076-5122)
- Christopher Lischer (ORCID: https://orcid.org/0000-0001-8876-7756)
- David Chambers (ORCID: https://orcid.org/0009-0002-1413-7801)
Institutions
- Tampere University of Applied Sciences (FI)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- German Climate Computing Centre (DE)
- Universitätsklinikum Erlangen (DE)
- Tampere University (FI)
- Leibniz-Institute for Food Systems Biology at the Technical University of Munich (DE)
- Comprehensive Cancer Center Erlangen (DE)
- University of Rostock (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-08-04
- DOI
- https://doi.org/10.1186/s13046-025-03478-5
- Citations
- 2
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- Deutsche Krebshilfe
- Universitätsklinikum Erlangen