A structure-based tool to interpret the significance of kinase mutations in clinical next generation sequencing in cancer
Though our tool is not expected to be used as an isolated source for variant functional prediction, we expect our database will be a valuable addition to the current tools and resources used to analyze clinical NGS, with important clinical implications to guide recommendations for personalized cancer therapy.
Authors
- Matthew P. Jacobson (ORCID: https://orcid.org/0000-0001-6262-655X)
- Emma L. Gunderson (ORCID: https://orcid.org/0000-0002-4038-5238)
- Ilona Sviezhentseva
- Amith Vikram Rangarajan (ORCID: https://orcid.org/0000-0003-2092-2232)
- Yana Pikman (ORCID: https://orcid.org/0000-0002-5336-0216)
- Beth Apsel Winger (ORCID: https://orcid.org/0000-0002-6909-8072)
Institutions
- Boston Children's Hospital (US)
- University of California, San Francisco (US)
- Dana-Farber Cancer Institute (US)
- Boston Children's Museum (US)
- University of San Francisco (US)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-08-04
- DOI
- https://doi.org/10.3389/fonc.2025.1599389
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00