The age of obesity onset affects changes in subcutaneous adipose tissue macrophages and T cells after weight loss
Our findings, though preliminary, do not support the hypothesis that SAT immune cell profiles account for the elevated type 2 diabetes risk in CO. Weight loss appears to alter some immune cell populations in AO but not in CO. The long-term metabolic consequences of these changes-or lack thereof-remain to be determined.
Authors
- Alexandra B. Cooke (ORCID: https://orcid.org/0000-0002-1081-8397)
- Stella S. Daskalopoulou (ORCID: https://orcid.org/0000-0003-4774-2549)
- Jessica Murphy (ORCID: https://orcid.org/0000-0001-8071-4457)
- Sylvia Santosa (ORCID: https://orcid.org/0000-0001-5814-6086)
- José A. Morais (ORCID: https://orcid.org/0000-0001-9366-6626)
- Michael A. Tsoukas (ORCID: https://orcid.org/0000-0002-8326-7274)
Institutions
- McGill University Health Centre (CA)
- Royal Victoria Hospital (CA)
- Concordia University (US)
- McGill University (CA)
- Concordia University (CA)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-08-04
- DOI
- https://doi.org/10.3389/fimmu.2025.1601847
- Citations
- 1
- Primary Topic
- Adipokines, Inflammation, and Metabolic Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- Concordia University
- Natural Sciences and Engineering Research Council of Canada
- Fonds de Recherche du Québec - Santé