A four-gene signature identified by integrated transcriptomic analysis for differential diagnosis and prognosis of uterine smooth muscle tumors
Our study identifies ABLIM1, FHL5, MAP3K8, and TOP2A as key molecular drivers of uterine smooth muscle tumorigenesis. The four-gene signature shows promise as a biomarker panel for early diagnosis and differentiation between tumor and normal tissues, providing a potential molecular foundation for targeted therapeutic strategies.
Authors
- Zhijie Xiao (ORCID: https://orcid.org/0000-0002-9050-8865)
- Bo Hong
- Y.Y. Chen (ORCID: https://orcid.org/0009-0003-7741-9547)
- Huiyi Hu (ORCID: https://orcid.org/0000-0002-4398-5167)
- Jing Li (ORCID: https://orcid.org/0000-0003-1222-7387)
- Jia Liu (ORCID: https://orcid.org/0000-0001-5678-7437)
- Zhiying Yu
- Yuchen Jiang (ORCID: https://orcid.org/0000-0002-3725-1650)
Institutions
- Sun Yat-sen University (CN)
- The Seventh Affiliated Hospital of Sun Yat-sen University (CN)
- Women's Hospital, School of Medicine, Zhejiang University (CN)
- Shenzhen Zhongshan Urological Hospital (CN)
- Shenzhen Second People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-08-04
- DOI
- https://doi.org/10.3389/fonc.2025.1591875
- Primary Topic
- Uterine Myomas and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China