Integrating network pharmacology and transcriptomics to identify solasonine’s anti-osteosarcoma targets and experimental validation
In this study, ATP1A1, CLK1, SIGMAR1, PYGM, and HSP90B1 were identified as key targets of solasonine in the treatment of OS, and they were found to have reference significance for the treatment of OS. SS can be a potential drug for the treatment of osteosarcoma.
Authors
- Min-Yu Li (ORCID: https://orcid.org/0000-0002-8564-8193)
- Daihao Wei
- Dawei Chu
- Jiandang Shi
Institutions
- Ningxia Medical University (CN)
- Ningxia Medical University General Hospital (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-08-04
- DOI
- https://doi.org/10.3389/fonc.2025.1614058
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00