Relationship between immunohistochemical markers and clinical pathological variables in clear cell renal cell carcinoma
Vimentin expression was strongly associated with markers of tumor invasiveness and may serve as a practical prognostic biomarker in ccRCC. Ki-67 may reflect proliferative activity and systemic burden. CD10 remains diagnostically useful but lacks prognostic value. Incorporating these IHC markers into routine pathology assessment may enhance risk stratification and inform individualized management of ccRCC with more exploration and validation.
Authors
- Pengshuai Liu (ORCID: https://orcid.org/0000-0001-9238-0490)
- Keyu Wei (ORCID: https://orcid.org/0000-0001-6715-837X)
- Shubo Chen
Institutions
- Hebei Medical University (CN)
- Affiliated Hospital of Chengde Medical College (CN)
- Chengde Medical University (CN)
- Xingtai People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-08-04
- DOI
- https://doi.org/10.3389/fonc.2025.1580024
- Citations
- 1
- Primary Topic
- Renal cell carcinoma treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.52