Relationship between immunohistochemical markers and clinical pathological variables in clear cell renal cell carcinoma

Vimentin expression was strongly associated with markers of tumor invasiveness and may serve as a practical prognostic biomarker in ccRCC. Ki-67 may reflect proliferative activity and systemic burden. CD10 remains diagnostically useful but lacks prognostic value. Incorporating these IHC markers into routine pathology assessment may enhance risk stratification and inform individualized management of ccRCC with more exploration and validation.

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Publication Details

Journal
Frontiers in Oncology
Published
2025-08-04
DOI
https://doi.org/10.3389/fonc.2025.1580024
Citations
1
Primary Topic
Renal cell carcinoma treatment
Type
article
Field-Weighted Citation Impact
1.52
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article

Relationship between immunohistochemical markers and clinical pathological variables in clear cell renal cell carcinoma

Pengshuai Liu, Keyu Wei, Shubo Chen
1 citations
Frontiers in Oncology
Renal cell carcinoma treatment
1.52
article

Relationship between immunohistochemical markers and clinical pathological variables in clear cell renal cell carcinoma

Pengshuai Liu, Keyu Wei, Shubo Chen
article en
1 citations

Abstract

Vimentin expression was strongly associated with markers of tumor invasiveness and may serve as a practical prognostic biomarker in ccRCC. Ki-67 may reflect proliferative activity and systemic burden. CD10 remains diagnostically useful but lacks prognostic value. Incorporating these IHC markers into routine pathology assessment may enhance risk stratification and inform individualized management of ccRCC with more exploration and validation.

Frontiers in OncologyVol. 15
Hebei Medical University (CN), Affiliated Hospital of Chengde Medical College (CN), Chengde Medical University (CN), Xingtai People's Hospital (CN)
Good health and well-being
Openalex Percentile: Top 16%
Renal cell carcinoma treatment
1.52
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