Statins regulate kinase signaling by causing changes in phosphorylation, rather than through changes in gene expression or direct inhibition: evidence in colorectal cancer
These findings suggest that the anticancer activity of statins may be mediated, at least in part, through their ability to modulate kinase phosphorylation and activity. This mechanistic insight supports further exploration of statins as modulators of kinase signaling in oncology.
Authors
- Robert Fredriksson (ORCID: https://orcid.org/0000-0002-2810-3226)
- Ludmila Jackeviča
- Maija Dambrova (ORCID: https://orcid.org/0000-0002-1739-0928)
- Francisco Alejandro Lagunas‐Rangel (ORCID: https://orcid.org/0000-0001-7730-6452)
- Jörgen Jönsson (ORCID: https://orcid.org/0000-0003-1995-1968)
- Helgi B. Schiöth
Institutions
- Uppsala University (SE)
- Latvijas Organiskās Sintēzes Institūts (LV)
- Riga Stradiņš University (LV)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-08-04
- DOI
- https://doi.org/10.3389/fphar.2025.1653702
- Citations
- 2
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- Cancerfonden
- Novo Nordisk
- Vetenskapsrådet
- Latvijas Zinātnes Padome