Zinc Ion‐Releasing Gelatin‐Based Bioadhesives for Wound Management

Traditional wound dressings, such as gauze and film, have been widely used to protect and close wound areas. However, they often face challenges, such as weak adhesion, incomplete hemostasis, and poor adaptability to irregular surfaces. Bioactive adhesive hydrogels have potential in wound healing because they seal wounds and actively promote tissue regeneration. Among the various strategies, incorporating bioactive inorganic ions, particularly zinc ions (Zn 2+ ), attracts increasing attention because of their crucial roles in hemostasis, immunomodulation, cell proliferation, angiogenesis, and collagen remodeling. Herein, Zn 2+ ‐releasing adhesive hydrogels are developed via ZnO 2 ‐mediated disulfide bonding, Zn 2+ ‐thiol metal coordination, and thiol‐ene reactions between thiolated and maleimide‐conjugated gelatin. These hydrogels exhibit tunable gelation time (11–21 s), mechanical strength (520–810 Pa), and enzymatic degradation behavior depending on the ZnO 2 concentration. They also provide sustained Zn 2+ and H 2 O 2 release for up to 21 days. Notably, the hydrogels show strong adhesion (142–165 kPa), outperforming fibrin glue, and adhere to various tissue surfaces. In vivo, Zn 2+ ‐releasing hydrogels significantly enhance wound healing by improving hemostasis, anti‐inflammatory effects, angiogenesis, and tissue remodeling. The results suggest that these hydrogels have substantial potential as multifunctional wound adhesives for effective wound management.