Biophysical and biochemical signatures of pancreatic stellate cell activation: insights into mechano-metabolic signalling from atomic force microscopy and Raman spectroscopy
Our findings reveal that pancreatic stellate cell activation involves a tightly coupled shift in mechanical and metabolic states, highlighting an integrated signalling process that may modulate stromal-vascular and stromal-epithelial communication. This mechano-metabolic axis represents a potential therapeutic target in fibrotic and neoplastic pancreatic diseases, where aberrant stromal signalling contributes to disease progression.
Authors
- Marta Targosz‐Korecka (ORCID: https://orcid.org/0000-0001-5650-7255)
- Monika A. Jakubowska (ORCID: https://orcid.org/0000-0002-4899-2606)
- Zbigniew Madeja (ORCID: https://orcid.org/0000-0002-5523-1215)
- Paweł E. Ferdek (ORCID: https://orcid.org/0000-0001-5582-6588)
- Jakub Dybaś (ORCID: https://orcid.org/0000-0003-2202-5068)
- Ewelina Wiercigroch (ORCID: https://orcid.org/0000-0002-6670-9405)
- Jacek J Litewka
- Natalia Cisak
Institutions
- Jagiellonian University (PL)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-08-04
- DOI
- https://doi.org/10.1186/s12964-025-02354-1
- Citations
- 2
- Primary Topic
- Pancreatitis Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.01
Funders
- Narodowe Centrum Nauki
- Narodowym Centrum Nauki