Telmisartan modulates exercise responses in peripheral artery disease: Analyses of skeletal muscle from the TELEX Trial
TEL may influence the effects of exercise on muscle in individuals with PAD by reducing myostatin expression, increasing myofiber size, and increasing activation of peroxisome proliferator-activated receptor gamma. Further study is needed to confirm these findings.
Authors
- James A. Stewart (ORCID: https://orcid.org/0000-0002-0976-2349)
- Kate Kosmac (ORCID: https://orcid.org/0000-0002-5247-4684)
- Luigi Ferrucci (ORCID: https://orcid.org/0000-0002-6273-1613)
- Jai K. Joshi (ORCID: https://orcid.org/0009-0003-1882-6353)
- Robert Sufit (ORCID: https://orcid.org/0000-0001-8827-2753)
- Mary Mcdermott (ORCID: https://orcid.org/0000-0002-3724-7619)
- Karen J. Ho (ORCID: https://orcid.org/0000-0002-7514-8953)
- Ahmed Ismaeel (ORCID: https://orcid.org/0000-0003-4025-3945)
- Dongxue Zhang (ORCID: https://orcid.org/0000-0003-2912-2020)
- Charlotte A. Peterson (ORCID: https://orcid.org/0000-0001-9340-0705)
- Shujun Xu (ORCID: https://orcid.org/0000-0002-2752-5507)
Institutions
- Northwestern University (US)
- University of Kentucky (US)
- Augusta University (US)
- Augusta University Health (US)
- Institute on Aging (US)
- National Institute on Aging (US)
Publication Details
- Journal
- JVS Vascular Science
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.jvssci.2025.100294
- Primary Topic
- Peripheral Artery Disease Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute on Aging
- National Heart, Lung, and Blood Institute