Pathogenic mechanisms of amyotrophic lateral sclerosis-linked VAPB P56S mutation in the degeneration of corticospinal motor neurons
These findings demonstrate the progressive degeneration of CSMNs induced by VAPB P56S mutation and indicate the involvement of the Ca<sup>2+</sup>-CaMKII-CRMP2 and IRE1-p38 MAPK/JNK-tau/p53 pathways in the pathogenic process.
Authors
- Huaibin Cai (ORCID: https://orcid.org/0000-0002-8596-6108)
- Jiayin Zheng (ORCID: https://orcid.org/0000-0002-8960-2790)
- Xinyu Wang (ORCID: https://orcid.org/0000-0002-1836-0202)
- Jia Yu (ORCID: https://orcid.org/0000-0002-1294-4856)
- Xuan Yang
Institutions
- National Institutes of Health (US)
- Beijing Geriatric Hospital (CN)
- National Institute on Aging (US)
Publication Details
- Journal
- Ageing and Neurodegenerative Diseases
- Published
- 2025-08-04
- DOI
- https://doi.org/10.20517/and.2025.21
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00