Mechanism of Inhibition of Apoptosis after Cerebral Hemorrhage by Acupuncture and Its Research Progress

脑出血(Intracerebral Hemorrhage, ICH)后细胞凋亡是受损脑组织迟发性细胞死亡的主要途径，是受凋亡基因控制的，主要存在于血肿周边较大范围的缺血水肿带中。针刺是一种传承百年的中医疗法，近年来针刺作为ICH的辅助治疗手段，其保护机制逐渐成为研究热点。本文以针刺抑制ICH后细胞凋亡的机制研究进展为切入点，通过梳理近20年来国内外关于ICH后细胞凋亡机制及针刺干预效果的研究。归纳发现针刺对于调控细胞凋亡信号通路、调控双通路靶向凋亡关键因子、调节自噬与凋亡的平衡、调节神经干细胞增殖与分化、抑制氧化应激通路、介导PAR-1蛋白表达等多个环节都有干预作用，为相关机制研究提供参考。Apoptosis after Intracerebral hemorrhage (ICH) is the main pathway of delayed cell death in damaged brain tissues, which is controlled by apoptosis genes, and mainly exists in the larger ischemic-edematous zone around the hematoma. Acupuncture is a centuries-old traditional Chinese medicine therapy, and in recent years, as an adjunctive treatment for ICH, its protective mechanism has gradually become a research hotspot. In this paper, we take the research progress on the mechanism of inhibition of apoptosis after ICH by acupuncture as an entry point, by combing the domestic and foreign studies on the mechanism of apoptosis after ICH and the effect of acupuncture intervention in the past 20 years. It was found that acupuncture has an intervention effect on regulating apoptosis signaling pathway, regulating dual pathway targeting apoptosis key factors, regulating the balance between autophagy and apoptosis, regulating the proliferation and differentiation of neural stem cells, inhibiting the oxidative stress pathway, and mediating the expression of PAR-1 protein, which can provide references to the research of related mechanisms.