Structure, Function, and Role of KCTD9 in Human Diseases

KCTD9 (新型钾通道相关基因)，是钾通道四聚化结构域(KCTD)基因家族的成员之一；因其N端保守的BTB结构域与电压门控钾通道具有序列相似性而得名，可以与CUL3相互作用介导靶蛋白的泛素化，并在NK细胞生长发育和功能发挥过程中发挥重要作用。起初的研究始于发现它在重型乙型肝炎中呈高表达，后续发现他还在几种恶性肿瘤中如肺癌、结直肠癌、乳腺癌发挥着重要的抗肿瘤作用。近年来关于KCTD9的研究报道逐渐增多，但对它的综述表述几乎没有，基于此我们对KCTD9的结构、功能以及在人类疾病中发挥的作用作了综述，并介绍了其所属KCTD家族的结构、功能及家族内成员在人类疾病中发挥的作用。KCTD9 (novel potassium channel-related gene) is a member of the potassium channel tetradomain (KCTD) gene family. It is named for its N-terminal conserved BTB domain, which shares sequence similarity with voltage-gated potassium channels. KCTD9 can interact with CUL3 to mediate the ubiquitination of target proteins and plays an important role in the growth, development, and function of NK cells. Initial studies began with the discovery of its high expression in severe hepatitis B, followed by findings of its important antitumor effects in several malignant tumors, such as lung cancer, colorectal cancer, and breast cancer. In recent years, reports on KCTD9 have increased, but there are almost no comprehensive reviews of it. Based on this, we provide a review of KCTD9’s structure, function, and role in human diseases, and introduce the structure, function, and role of its family members in human diseases.