Efficacy and Safety of Mirabegron and Tamsulosin Combination Therapy Compared to Tamsulosin Monotherapy for Lower Urinary Tract Symptoms Due to Benign Prostatic Hyperplasia: Results of a Multicenter, Randomized, Double-Blind, Phase III Clinical Trial
Combination therapy with mirabegron and tamsulosin is more effective than monotherapy in improving LUTS in patients with BPH, particularly storage symptoms, with a comparable safety profile. A fixed-dose combination formulation in the future may further improve patient adherence and quality of life.
Authors
- Won Ki Lee (ORCID: https://orcid.org/0000-0001-7172-0636)
- Tae Hyo Kim
- Sung‐Hoo Hong (ORCID: https://orcid.org/0000-0002-1952-4010)
- Kyung Jin Chung (ORCID: https://orcid.org/0000-0003-0153-7814)
- Sung Chul Kam (ORCID: https://orcid.org/0000-0001-5403-3623)
- Yu Seob Shin (ORCID: https://orcid.org/0000-0002-1126-3821)
- Phil Hyun Song (ORCID: https://orcid.org/0000-0002-3801-258X)
- Deok Hyun Han (ORCID: https://orcid.org/0000-0002-9962-802X)
- Kang Su Cho (ORCID: https://orcid.org/0000-0002-3500-8833)
- Sung Tae Cho (ORCID: https://orcid.org/0000-0002-4691-6159)
- Sung Yul Park (ORCID: https://orcid.org/0000-0002-9777-9238)
- Jae Hyun Bae (ORCID: https://orcid.org/0000-0001-9862-3545)
- Tae Nam Kim
- Won Sik Ham (ORCID: https://orcid.org/0000-0003-2246-8838)
- Doo Sang Kim (ORCID: https://orcid.org/0000-0001-6405-1294)
- Tae‐Hwan Kim (ORCID: https://orcid.org/0000-0003-4924-4826)
- Young Seop Chang
- Zhao Luo (ORCID: https://orcid.org/0009-0005-7807-6296)
- Joon Hwa Noh
Institutions
- Hallym University (KR)
- Changwon National University (KR)
- Gyeongsang National University (KR)
- Yonsei University (KR)
- Korea University (KR)
- Soonchunhyang University (KR)
- Dong-A University Hospital (KR)
- Ansan University (KR)
- Kyungpook National University (KR)
- Sacred Heart Hospital (NG)
- Kwangju Christian Hospital (KR)
- Gachon University Gil Medical Center (KR)
- Longgang Central Hospital (CN)
- Hallym University Kangnam Sacred Heart Hospital (KR)
- Pusan National University Hospital (KR)
- Daejeon Sun Hospital (KR)
- Jeonbuk National University Hospital (KR)
- Gangnam Severance Hospital (KR)
- The Catholic University of Korea Seoul St. Mary's Hospital (KR)
- Yeungnam University College
- Hanyang University (KR)
- Yeungnam University (KR)
- Sungkyunkwan University (KR)
- Catholic University of Korea (KR)
Publication Details
- Journal
- The World Journal of Men s Health
- Published
- 2025-08-03
- DOI
- https://doi.org/10.5534/wjmh.250085
- Citations
- 1
- Primary Topic
- Urinary Bladder and Prostate Research
- Type
- article
- Field-Weighted Citation Impact
- 1.84