A CD24+CD271+ melanoma cancer stem cell possesses hybrid characteristics of its single marker counterparts and promotes invasion and therapeutic resistance
The lack of CD24<sup>+</sup>CD271<sup>-</sup> and CD24<sup>+</sup>CD271<sup>+</sup> stem cells in the majority of human melanoma specimens led us to conclude that they may be dispensable for melanoma progression. Nevertheless, the enhanced sphere formation, lineage plasticity, migratory ability and drug resistance of the CD24<sup>+</sup>CD271<sup>+</sup> sub-population may signal a contextual requirement for these stem cells when melanomas face challenging environments both clinically and in experimental systems.
Authors
- Adrian Biddle (ORCID: https://orcid.org/0000-0003-4371-9720)
- Hasan Rizvi (ORCID: https://orcid.org/0000-0001-9013-0324)
- Catherine Harwood (ORCID: https://orcid.org/0000-0002-1375-0965)
- Sophia Lunetto
- Gehad Youssef (ORCID: https://orcid.org/0000-0002-9998-1384)
- Michael P. Philpott (ORCID: https://orcid.org/0000-0002-1255-4612)
- Daniele Bergamaschi (ORCID: https://orcid.org/0000-0002-3955-1091)
- Olivia Knowles (ORCID: https://orcid.org/0000-0002-0146-4865)
- Patricio Doldan (ORCID: https://orcid.org/0000-0003-3900-7480)
- Isabella Hillier-Richardson
- Luke Gammon (ORCID: https://orcid.org/0000-0002-1233-2665)
- Ian C. Mackenzie
- Stephanie Lunt
Institutions
- Queen Mary University of London (GB)
- Barts Health NHS Trust (GB)
Publication Details
- Journal
- BMC Biology
- Published
- 2025-08-03
- DOI
- https://doi.org/10.1186/s12915-025-02336-2
- Citations
- 1
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- Queen Mary University of London
- Barts Charity
- Animal Free Research UK
- Medical Research Council