Function of 18F-FDG PET/CT radiomics in the detection of checkpoint inhibitor-induced liver injury (CHILI)
This pilot study identified statistically significant differences in PET-derived radiomics features of the spleen and observable changes in the liver on PET/CT scans before and after the onset of CHILI. Identifying these features could aid in diagnosing or predicting CHILI, potentially enabling personalized treatment. Larger multicenter prospective studies are needed to confirm these findings and develop automated detection methods.
Authors
- Sofiya Latifyan (ORCID: https://orcid.org/0000-0001-5117-069X)
- Mario Jreige (ORCID: https://orcid.org/0000-0003-3918-150X)
- John Olivier Prior (ORCID: https://orcid.org/0000-0003-1429-1374)
- Daniel Abler (ORCID: https://orcid.org/0000-0003-1776-5985)
- Adrien Depeursinge (ORCID: https://orcid.org/0000-0002-2362-0304)
- Alexander Coukos (ORCID: https://orcid.org/0000-0003-4869-3160)
- Marie Nicod Lalonde (ORCID: https://orcid.org/0000-0002-4886-0611)
- Niklaus Schaefer (ORCID: https://orcid.org/0000-0002-9732-7696)
- Montserrat Fraga (ORCID: https://orcid.org/0000-0001-9408-3094)
- Clémence M C Huigen
Institutions
- Centre Hospitalier Universitaire Vaudois (CH)
- University Hospital of Geneva (CH)
- HES-SO Valais-Wallis (CH)
- University of Lausanne (CH)
Publication Details
- Journal
- EJNMMI Reports
- Published
- 2025-08-03
- DOI
- https://doi.org/10.1186/s41824-025-00258-4
- Primary Topic
- Radiomics and Machine Learning in Medical Imaging
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Université de Lausanne
- Centre Hospitalier Universitaire Vaudois