Cluster analysis reveals distinct inflammatory phenotypes in cardiometabolic disease
This study identified three clinically distinct inflammatory phenotypes in cardiometabolic diseases, with T2DM exacerbating systemic inflammation in patients with pre-existing CVD. The discordant phenotype (high CVD burden but low TNF-α levels) challenges current inflammatory models and suggests alternative pathways in some patients. These findings support the need for phenotype-specific approaches for risk stratification and targeted anti-inflammatory therapies in high-risk subgroups.
Authors
- Bruna Dias de Lima Fragelli (ORCID: https://orcid.org/0000-0002-3970-7834)
- Carlos Speglich
- L Branco (ORCID: https://orcid.org/0000-0002-7992-0365)
- Henrique Pott (ORCID: https://orcid.org/0000-0003-3126-2946)
- Joice Margareth de Almeida Rodolpho (ORCID: https://orcid.org/0000-0002-1277-0083)
- Matteo Esposito (ORCID: https://orcid.org/0000-0003-0609-6333)
- Luciana Camillo (ORCID: https://orcid.org/0000-0002-7070-9184)
- Jaqueline Bianchi (ORCID: https://orcid.org/0000-0002-7385-1354)
- Meliza Goi Roscani (ORCID: https://orcid.org/0000-0003-1463-551X)
- Krissia Franco de Godoy
- Fernanda de Freitas Anibal
- Fernanda Oliveira Duarte
Institutions
- Universidade Federal de São Carlos (BR)
- Petrobras (Brazil) (BR)
Publication Details
- Journal
- Cardiovascular Diabetology – Endocrinology Reports
- Published
- 2025-08-03
- DOI
- https://doi.org/10.1186/s40842-025-00227-7
- Citations
- 4
- Primary Topic
- Adipokines, Inflammation, and Metabolic Diseases
- Type
- article
- Field-Weighted Citation Impact
- 5.42
Funders
- Petrobras