A framework of biomarkers for adipose tissue aging: a consensus statement by the Aging Biomarker Consortium
Adipose tissue serves as a crucial energy storage and metabolic organ in the human body. With the surging of elderly population in China comes significant challenges in preventing and managing age-associated diseases, while adipose tissue aging represents one of the pivotal initiating events for multi-organ senescence. To address these challenges, the Aging China Biomarkers Consortium (ABC) has established an expert consensus on biomarkers of adipose tissue aging by digesting literature and collecting insights from scientists and clinicians. This consensus provides a comprehensive evaluation of the key changes and characteristics, as well as biomarkers related to adipose tissue aging and proposes a systematic framework categorizing these biomarkers into functional, structural and humoral dimensions. Within each dimension, the ABC recommends clinically and empirically validated biomarkers and parameters for assessing both physiological and pathological changes in adipose tissue during aging, which aims to establish a foundation for future prediction, diagnosis, early warning and treatment for adipose tissue aging and its related diseases, with the ultimate goal of improving adipose tissue health and promoting healthy aging in elderly populations both in China and worldwide.
Authors
- Jiajun Zhao (ORCID: https://orcid.org/0000-0003-3267-9292)
- Lixin Guo (ORCID: https://orcid.org/0000-0001-6863-1798)
- Jianping Weng (ORCID: https://orcid.org/0000-0002-7889-1697)
- Xinran Ma (ORCID: https://orcid.org/0000-0003-4968-6536)
- Aimin Xu (ORCID: https://orcid.org/0000-0002-0668-033X)
- Cheng Hu (ORCID: https://orcid.org/0000-0003-4316-231X)
- Xiangqing Kong (ORCID: https://orcid.org/0000-0003-3309-1140)
- Qi‐Qun Tang (ORCID: https://orcid.org/0000-0002-0285-7425)
- Tong‐Jin Zhao (ORCID: https://orcid.org/0000-0001-6861-3071)
- Guang Ning (ORCID: https://orcid.org/0000-0002-5754-7635)
- Jing Qu (ORCID: https://orcid.org/0000-0002-3988-5067)
- Cong-Yi Wang
- Jiqiu Wang (ORCID: https://orcid.org/0000-0002-9383-7656)
- Jingjing Zhang (ORCID: https://orcid.org/0000-0002-9155-8979)
- Yan Chen (ORCID: https://orcid.org/0000-0002-6630-0693)
- Jian Li (ORCID: https://orcid.org/0000-0003-3320-7924)
- Qiang Li (ORCID: https://orcid.org/0000-0003-3831-9001)
- Yan Bi (ORCID: https://orcid.org/0000-0003-3914-7854)
- Ting Zhang (ORCID: https://orcid.org/0000-0003-4229-6332)
- Huijie Zhang (ORCID: https://orcid.org/0000-0003-0640-0315)
- Qiang Li (ORCID: https://orcid.org/0000-0002-9825-5313)
- Weiqi Zhang (ORCID: https://orcid.org/0000-0002-8885-5104)
- Guang‐Hui Liu (ORCID: https://orcid.org/0000-0001-9289-8177)
- Weiping Zhang (ORCID: https://orcid.org/0000-0001-7206-5901)
- Zhe Dai (ORCID: https://orcid.org/0000-0003-0321-0225)
- Gang Pei (ORCID: https://orcid.org/0000-0002-4330-2530)
- Feifan Guo (ORCID: https://orcid.org/0000-0003-3137-9781)
- Pingsheng Liu (ORCID: https://orcid.org/0000-0002-2599-9004)
- Jinhua Yu (ORCID: https://orcid.org/0000-0003-4874-9910)
Institutions
- Tongji University (CN)
- Shanghai Medical College of Fudan University (CN)
- Central South University (CN)
- Army Medical University (CN)
- Chinese University of Hong Kong (HK)
- Shanghai Jiao Tong University (CN)
- Anhui Medical University (CN)
- Chinese Academy of Sciences (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- Harbin Institute of Technology (CN)
- Fudan University (CN)
- Ruijin Hospital (CN)
- Beijing Institute of Genomics (CN)
- Wuhan University (CN)
- Zhengzhou University (CN)
- Beijing Geriatric Hospital (CN)
- Institute for Stem Cell Biology and Regenerative Medicine (IN)
- Daping Hospital (CN)
- Shanghai Institute of Nutrition and Health (CN)
- Nanfang Hospital (CN)
- Nanjing Drum Tower Hospital (CN)
- Institute of Biophysics (CN)
- Shandong Provincial Hospital (CN)
- Zhongnan Hospital of Wuhan University (CN)
- Institute of Zoology (KZ)
- Regenerative Medicine Institute (MX)
- Shanghai Sixth People's Hospital (CN)
- Jiangsu Province Hospital (CN)
- Second Xiangya Hospital of Central South University (CN)
- Tongji Hospital (CN)
- Shandong First Medical University (CN)
- Institute of Zoology (CN)
- Huazhong University of Science and Technology (CN)
- Southern Medical University (CN)
- East China Normal University (CN)
- Nanjing Medical University (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Life Medicine
- Published
- 2025-07-19
- DOI
- https://doi.org/10.1093/lifemedi/lnaf027
- Citations
- 2
- Primary Topic
- Genetics, Aging, and Longevity in Model Organisms
- Type
- article
- Field-Weighted Citation Impact
- 1.91