A mitochondrial-derived peptide MOTS-c contributes to the protective effect against brain injury associated with LPS-induced sepsis by strengthening the blood-brain barrier’s ultrastructure
MOTS-c effectively reduced mortality rates and the MSS, attenuated neuroinflammatory responses, mitigated increase in BBB permeability, promoted neurotrophic factor production, and protecting against brain injury in mice with LPS-induced sepsis.
Authors
- Yang Guo (ORCID: https://orcid.org/0000-0002-5673-3989)
- Yuanyuan Bai (ORCID: https://orcid.org/0000-0002-4059-6334)
- Beibei Dong (ORCID: https://orcid.org/0000-0002-9711-2353)
- Yonghao Yu (ORCID: https://orcid.org/0000-0002-7289-7748)
- Xu Wang (ORCID: https://orcid.org/0009-0000-6978-3718)
- Bo Gong (ORCID: https://orcid.org/0000-0001-8013-4196)
- Haiyan Wu (ORCID: https://orcid.org/0000-0002-7940-4782)
Institutions
- Tianjin Medical University General Hospital (CN)
- Linyi People's Hospital (CN)
- First Teaching Hospital of Tianjin University of Traditional Chinese Medicine (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- International Journal of Neuroscience
- Published
- 2025-08-03
- DOI
- https://doi.org/10.1080/00207454.2025.2542883
- Citations
- 2
- Primary Topic
- Intensive Care Unit Cognitive Disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.09