Metabolic stability assay in human, rat, dog or mouse hepatocytes v1

Metabolic stability, measured in hepatocytes,refers to the rate at which a drug compound is metabolized or broken down by liver cells.This is a critical aspect of drug discovery and development, as it helps determine how long a drug will remain in the body and at what concentration it will exert its therapeutic effect.In drug development, understanding metabolic stability is crucial for identifying compounds that are stable enough to reach their target and for optimizing chemical structures to improve metabolic stability.

Authors

Publication Details

Published
2025-05-25
DOI
https://doi.org/10.17504/protocols.io.14egnykbqv5d/v1
Primary Topic
Liver Disease Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Metabolic stability assay in human, rat, dog or mouse hepatocytes v1

Nick Lynch
Liver Disease Diagnosis and Treatment
article

Metabolic stability assay in human, rat, dog or mouse hepatocytes v1

Nick Lynch
article en

Abstract

Metabolic stability, measured in hepatocytes,refers to the rate at which a drug compound is metabolized or broken down by liver cells.This is a critical aspect of drug discovery and development, as it helps determine how long a drug will remain in the body and at what concentration it will exert its therapeutic effect.In drug development, understanding metabolic stability is crucial for identifying compounds that are stable enough to reach their target and for optimizing chemical structures to improve metabolic stability.

Openalex Percentile: Top 73%
Liver Disease Diagnosis and Treatment
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Metabolic stability assay in human, rat, dog or mouse hepatocytes v1 — Nick Lynch · (2025) | TGRS Research Map | TGRS