Evaluation and Comparison of Ketoconazole and Alkaline Glutaraldehyde Effects on Candida albicans Adherence to Three Denture Base Materials: An In Vitro Study

Both ketoconazole and alkaline glutaraldehyde effectively reduced <i>C. albicans</i> adherence, but alkaline glutaraldehyde demonstrated a faster and more potent antimicrobial action, particularly on injectable denture materials, making it suitable for rapid disinfection. Ketoconazole showed gradual and sustained efficacy, which is ideal for long-term fungal control.

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Publication Details

Journal
Cureus
Published
2025-08-03
DOI
https://doi.org/10.7759/cureus.89273
Primary Topic
Antifungal resistance and susceptibility
Type
article
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0.00
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article

Evaluation and Comparison of Ketoconazole and Alkaline Glutaraldehyde Effects on Candida albicans Adherence to Three Denture Base Materials: An In Vitro Study

Gudikandula Krishna, Gottumukkala Vineela, Palakayala Balaswamy, Deepthi Batthula et al.
Cureus
Antifungal resistance and susceptibility
article

Evaluation and Comparison of Ketoconazole and Alkaline Glutaraldehyde Effects on Candida albicans Adherence to Three Denture Base Materials: An In Vitro Study

Gudikandula Krishna, Gottumukkala Vineela, Palakayala Balaswamy, Deepthi Batthula, Rophica J Mitta, Shyni R Gorremutchu
article en

Abstract

Both ketoconazole and alkaline glutaraldehyde effectively reduced <i>C. albicans</i> adherence, but alkaline glutaraldehyde demonstrated a faster and more potent antimicrobial action, particularly on injectable denture materials, making it suitable for rapid disinfection. Ketoconazole showed gradual and sustained efficacy, which is ideal for long-term fungal control.

CureusVol. 17(8)
Kamineni Institute of Dental Sciences (IN)
Zero hunger
Openalex Percentile: Top 76%
Antifungal resistance and susceptibility
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