Differential effects of soluble and plaque amyloid on late-life depression: The moderating role of tau pathology
The association between amyloid pathology and depression differs depending on tau burden. Soluble OAβ may be a key contributor to depressive symptoms in early AD stages, while plaque effects become prominent later. These findings underscore the potential utility of OAβ as an early neuropsychiatric biomarker in AD and highlight the need to consider tau pathology when evaluating amyloid-related mood disturbances.
Authors
- Hyun Kook Lim (ORCID: https://orcid.org/0000-0001-8742-3409)
- Sonya Youngju Park
- Seunggyun Ha (ORCID: https://orcid.org/0000-0003-2016-1373)
- Dong Woo Kang (ORCID: https://orcid.org/0000-0003-3289-075X)
- Yeong Sim Choe
- Yoo Hyun Um (ORCID: https://orcid.org/0000-0002-3403-4140)
- Sheng‐Min Wang
- Suhyung Kim (ORCID: https://orcid.org/0000-0003-3719-5270)
- Gihwan Byeon (ORCID: https://orcid.org/0000-0002-7452-3440)
- Chang Uk Lee (ORCID: https://orcid.org/0000-0001-6398-7330)
- Donghyeon Kim (ORCID: https://orcid.org/0000-0003-3808-795X)
- Sunghwan Kim (ORCID: https://orcid.org/0000-0001-6455-4369)
Institutions
- St. Mary's Hospital (US)
- The Catholic University of Korea St. Vincent's Hospital (KR)
- The Seoul Institute (KR)
- The Catholic University of Korea Yeouido St. Mary's Hospital (KR)
- St Mary's Hospital (GB)
- The Catholic University of Korea Seoul St. Mary's Hospital (KR)
- Catholic University of Korea (KR)
Publication Details
- Journal
- The Journal of Prevention of Alzheimer s Disease
- Published
- 2025-08-05
- DOI
- https://doi.org/10.1016/j.tjpad.2025.100318
- Citations
- 1
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 1.47