HDM-2-Targeting Peptide PNC-27 Kills Cervical Cancer Cells but not Normal Cervical Cells.
PNC-27 kills cervical squamous cancer but not normal cervical cells due to the unique expression of HDM-2 in the cervical squamous cell membranes. Thus, PNC-27 may be an effective drug against this cancer. Our results further suggest that the expression of membrane-bound HDM-2 on cervical cancer cells is stable both in cell culture media and in alcoholic preservative fluid.
Authors
- Shabnam Seydafkan
- Alfred Shim
- Prem K. Premsrirut (ORCID: https://orcid.org/0000-0002-5950-5412)
- Paul W. Brandt‐Rauf (ORCID: https://orcid.org/0000-0001-5561-4681)
- Matthew R. Pincus (ORCID: https://orcid.org/0000-0003-3228-096X)
- Richard D. Feinman (ORCID: https://orcid.org/0000-0001-9151-2447)
- Hui Ting Chen
- Miriam Silberstein
- Anna I Miller
- Ehsan Yazdi
- Patryck K Krzesaj
- Gholamali Jahari
- Steven Mcglinchey
Institutions
- Drexel University (US)
Publication Details
- Journal
- PubMed
- Published
- 2025-05-01
- Primary Topic
- Lung Cancer Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00