Corticobasal degeneration preceded by cognitive impairment and apathy: An autopsy case report
In this case, abundant tau pathology in the frontal lobe corresponded with early cognitive impairment, including frontal lobe dysfunction, whereas abundant tau pathology in the basal ganglia corresponded with rapid exacerbation of extrapyramidal symptoms and marked reduction in DAT availability. Clinicians should be aware that patients with CBD without motor symptoms may seek treatment at outpatient clinics specializing in dementia.
Authors
- Shinobu Kawakatsu (ORCID: https://orcid.org/0000-0003-4074-1041)
- Kumiko Utsumi (ORCID: https://orcid.org/0000-0003-2781-3303)
- Chiaki Kawanishi (ORCID: https://orcid.org/0000-0003-3464-3787)
- Ryota Kobayashi (ORCID: https://orcid.org/0000-0002-4213-618X)
- S. Hirose
- Akihito Suzuki (ORCID: https://orcid.org/0000-0002-5526-9141)
- Shigeki Hatakeyama
Institutions
- Yamagata University (JP)
- Fukushima Medical University (JP)
- Sapporo Medical University (JP)
- Sunagawa City Medical Center (JP)
Publication Details
- Journal
- Psychiatry and Clinical Neurosciences Reports
- Published
- 2025-08-03
- DOI
- https://doi.org/10.1002/pcn5.70174
- Citations
- 1
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Ministry of Health, Labour and Welfare