DIO3 depletion attenuates ovarian cancer growth via reduced glycolysis and alterations in glutamine metabolism
These collective findings position DIO3 as a potential regulator of ovarian cancer metabolism, with implications for targeting this enzyme to disrupt tumor energetics as a novel therapeutic approach.
Authors
- Govindasamy Mugesh (ORCID: https://orcid.org/0000-0002-5389-5309)
- Maya Gottfried
- Bernard Lerer (ORCID: https://orcid.org/0000-0002-9914-632X)
- Osnat Ashur‐Fabian (ORCID: https://orcid.org/0000-0001-8624-3182)
- Dotan Moskovich
- Tzuri Lifschytz
- Amit Rosemarin
- Aileen Cleary Cohen
- Itai Fabian
- Daniel Beilinson
Institutions
- Tel Aviv University (IL)
- Hadassah Medical Center (IL)
- Meir Medical Center (IL)
- Indian Institute of Science Bangalore (IN)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2025-07-30
- DOI
- https://doi.org/10.1016/j.molmet.2025.102225
- Citations
- 2
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.87