Conditioned medium from brachytherapy-irradiated hepatocellular carcinoma cells drives SASP-mediated senescence in naïve cellular counterparts
In vitro brachytherapy triggers a bystander effect in HCC cells via SASP-associated proteins inducing senescence in neighboring cells. Modulating senescence or its associated secretory phenotype may offer a novel target for therapy in future trials.
Authors
- Elif Öcal (ORCID: https://orcid.org/0000-0003-1909-3713)
- Shraga Nahum Goldberg (ORCID: https://orcid.org/0000-0003-2940-9822)
- Matthias Stechele (ORCID: https://orcid.org/0000-0003-1810-3529)
- J. Well
- Stephanie Corradini
- Philipp M. Kazmierczak (ORCID: https://orcid.org/0000-0003-0071-1665)
- Jens Ricke (ORCID: https://orcid.org/0000-0001-8762-8594)
- Heidrun Hirner-Eppeneder
- Marianna Alunni‐Fabbroni (ORCID: https://orcid.org/0000-0002-9710-1662)
- Lukas Salvermoser (ORCID: https://orcid.org/0000-0001-7878-4245)
- Moritz Nikolaus Gröper (ORCID: https://orcid.org/0009-0004-1965-7675)
- J. Schäfer
- Josephine Naruhn
Institutions
- Hadassah Medical Center (IL)
- LMU Klinikum (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Radiotherapy and Oncology
- Published
- 2025-07-30
- DOI
- https://doi.org/10.1016/j.radonc.2025.111068
- Citations
- 2
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 2.33