BCL-2/BCL-XL dual inhibition triggers Gasdermin D-mediated pyroptosis in mantle cell lymphoma
• Dual BCL-2/BCL-X L inhibition has shown compelling efficacy in overcoming drug resistance in mantle cell lymphoma. • The induced pyroptosis in MCL is mediated through a BAK/BAX-dependent pathway. • The identified pyroptosis mechanism suggests a novel combination strategy with immunotherapies for cancer treatment.
Authors
- Jovanny Vargas (ORCID: https://orcid.org/0000-0002-8606-2610)
- Celeste Lee
- Ching-Fei Li (ORCID: https://orcid.org/0000-0001-7844-7003)
- Fangfang Yan (ORCID: https://orcid.org/0000-0001-6231-5225)
- Yixin Yao (ORCID: https://orcid.org/0000-0002-8439-6043)
- Changying Jiang (ORCID: https://orcid.org/0000-0003-3778-4438)
- Heng‐Huan Lee (ORCID: https://orcid.org/0000-0002-7813-1292)
- Joseph Mitchell McIntosh
- Yang Liu (ORCID: https://orcid.org/0000-0002-1910-8076)
- Wei Wang (ORCID: https://orcid.org/0000-0002-0600-7276)
- Michael L. Wang (ORCID: https://orcid.org/0000-0001-9748-5486)
- Lei Nie (ORCID: https://orcid.org/0000-0002-6175-5883)
- Yijing Li (ORCID: https://orcid.org/0000-0002-0677-2664)
- Yue Fei (ORCID: https://orcid.org/0009-0003-9421-0665)
- Yuxuan Che (ORCID: https://orcid.org/0000-0002-0714-6411)
Institutions
- The University of Texas MD Anderson Cancer Center (US)
Publication Details
- Journal
- Cancer Letters
- Published
- 2025-08-03
- DOI
- https://doi.org/10.1016/j.canlet.2025.217961
- Citations
- 3
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.42