Exploring the causal genetic relationship between 41 inflammatory cytokines and osteoporosis: a bidirectional Mendelian randomization analysis
This is the first bidirectional MR analysis to explore the causal genetic relationship between inflammatory cytokines and osteoporosis. This study found that MCP-1 and TRAIL are probably the upstream factors correlated with osteoporosis, and no inflammatory cytokine was involved in osteoporosis development downstream.
Authors
- Xinge Shi
- Weiran Hu (ORCID: https://orcid.org/0000-0001-7924-7820)
- Kai Zhang (ORCID: https://orcid.org/0000-0001-8581-9063)
- Chuang Wang (ORCID: https://orcid.org/0000-0002-6220-0126)
- Hongqiang Wang (ORCID: https://orcid.org/0000-0003-1262-1958)
- Runze Liu (ORCID: https://orcid.org/0000-0002-3052-3481)
Institutions
- Zhengzhou University (CN)
- Xintai People's Hospital (CN)
- Henan Provincial People's Hospital (CN)
- Zhengzhou People's Hospital (CN)
Publication Details
- Journal
- SAGE Open Medicine
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1177/20503121251360176
- Citations
- 1
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.82