Amblyostatin-1, the first salivary cystatin with host immunomodulatory and anti-inflammatory properties from the Neotropical tick <i>Amblyomma sculptum</i>, vector of Brazilian spotted fever.
These findings establish Amblyostatin-1 as a novel salivary cystatin with immunomodulatory and anti-inflammatory properties, highlighting its potential as an immunobiological agent.
Authors
- Michail Kotsyfakis (ORCID: https://orcid.org/0000-0002-7526-1876)
- Zdeněk Franta (ORCID: https://orcid.org/0000-0002-7709-0097)
- Mohamed Amine Jmel (ORCID: https://orcid.org/0000-0002-9978-3409)
- José M. Medina (ORCID: https://orcid.org/0000-0002-8977-0663)
- Josiane Betim de Assis (ORCID: https://orcid.org/0000-0001-6549-912X)
- Aparecida S. Tanaka (ORCID: https://orcid.org/0000-0001-9407-805X)
- Andréa Cristina Fogaça (ORCID: https://orcid.org/0000-0002-0890-6136)
- Lucas Tirloni (ORCID: https://orcid.org/0000-0003-4582-7100)
- Gabriel Cerqueira Alves Costa (ORCID: https://orcid.org/0000-0003-1772-2336)
- Eliane Esteves (ORCID: https://orcid.org/0000-0002-4347-798X)
- Anderson Sá‐Nunes (ORCID: https://orcid.org/0000-0002-1859-4973)
- Wilson Santos Molari
- Alan Frazão-Silva
- Júlia Moura Bernardi
- Gretta Huamanrayme
- Solange Cristina Antão
Institutions
- Centre National de la Recherche Scientifique (FR)
- Sewanee: The University of the South (US)
- Universidad de Granada (ES)
- Universidade de São Paulo (BR)
- University of South Bohemia in České Budějovice (CZ)
- Institute of Parasitology of the Slovak Academy of Sciences (SK)
- National Institute of Allergy and Infectious Diseases (US)
- Ingénierie Moléculaire et Physiopathologie Articulaire (FR)
- Institute of Biomedical Science (GB)
- National Institute of Science and Technology (ID)
- University of South Alabama (US)
- Universidade Federal de São Paulo (BR)
- Foundation for Research and Technology Hellas (GR)
- Université de Lorraine (FR)
Publication Details
- Journal
- PubMed
- Published
- 2025-01-01
- DOI
- https://doi.org/10.3389/fimmu.2025.1585703
- Primary Topic
- Vector-borne infectious diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- European Regional Development Fund
- National Institute of Allergy and Infectious Diseases