A feasibility study of enzymatic methylation sequencing of cell-free DNA from cerebrospinal fluid of pediatric central nervous system tumor patients for molecular classification
This study demonstrated the feasibility of CNS tumor molecular classification based on CSF using the EM-seq approach, and establishes potential sample quality limitations for future studies.
Authors
- Aaron Taylor (ORCID: https://orcid.org/0000-0002-2544-5888)
- Markus J. Bookland (ORCID: https://orcid.org/0000-0003-4422-8376)
- Joanna J. Gell (ORCID: https://orcid.org/0000-0002-1176-8272)
- Jonathan E. Martin (ORCID: https://orcid.org/0000-0003-3180-2084)
- Ching C. Lau (ORCID: https://orcid.org/0000-0001-9173-8366)
- David S. Hersh (ORCID: https://orcid.org/0000-0003-1177-2201)
- Felix Sahm (ORCID: https://orcid.org/0000-0001-5441-1962)
- Evan Cantor (ORCID: https://orcid.org/0000-0001-7302-9734)
- Areeba Patel (ORCID: https://orcid.org/0000-0003-0374-4227)
- Patrick Kwok‐Shing Ng (ORCID: https://orcid.org/0000-0003-0364-7443)
- Jody T Lombardi
- Xianyuan Song
- Ariella Tamariz
Institutions
- Hartford Hospital (US)
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- Connecticut Children's Medical Center (US)
- Jackson Laboratory (US)
- UConn Health (US)
Publication Details
- Journal
- Neuro-Oncology Advances
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1093/noajnl/vdaf159
- Citations
- 1
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- U.S. Department of Defense
- CureSearch for Children's Cancer
- Strong
- Connecticut Children's Medical Center
- DOD Peer Reviewed Cancer Research Program