Development of a human colorectal carcinoma cell-based platform for studying inducible nitric oxide synthase expression and nitric oxide signaling dynamics.
Our findings establish the DLD-1 cell line as a reproducible and well-controlled in vitro system for studying inducible iNOS expression and downstream NO/RNS signaling in human epithelial cancer cells. This platform provides a valuable tool for mechanistic studies, screening of iNOS-targeted agents, and resolving discrepancies in iNOS detection across experimental models in cancer biology.
Authors
- Yong Qin (ORCID: https://orcid.org/0000-0003-4743-938X)
- Elizabeth A. Grimm (ORCID: https://orcid.org/0000-0001-7140-0587)
- Xi Chen (ORCID: https://orcid.org/0009-0005-2765-6653)
Institutions
- The University of Texas at El Paso (US)
Publication Details
- Journal
- PubMed
- Published
- 2025-01-01
- DOI
- https://doi.org/10.3389/fmolb.2025.1637230
- Primary Topic
- Nitric Oxide and Endothelin Effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00