Impact of administration route and gene polymorphisms on the serum concentration of voriconazole among Chinese patients with hematologic malignancies.
The C<sub>min</sub> of intravenous VRC was greater than the C<sub>min</sub> of oral VRC when patients were treated with the recommended dosage. Oral administration of VRC via Q12h is optimal for obtaining a higher C<sub>min</sub> of serum VRC. Furthermore, attention should be given to VRC serum concentrations in patients with mutations in <i>CYP2C19</i>. The <i>CYP3A4</i> rs2242480 and <i>CYP3A4</i> rs4646437 genotypes may primarily affect VRC concentrations during intravenous administration, whereas <i>ABCB1</i> rs1128503 primarily affects VRC concentrations during oral administration.
Authors
- Liyan Miao
- Zhiyao Chen (ORCID: https://orcid.org/0000-0001-6918-4053)
- Lin Wang (ORCID: https://orcid.org/0000-0003-2433-8594)
- Yuzhu Cheng
- Menghua Zhang (ORCID: https://orcid.org/0000-0001-5326-6994)
Institutions
- Soochow University (CN)
- Suzhou Vocational Health College (CN)
- First Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-01-01
- DOI
- https://doi.org/10.3389/fphar.2025.1445583
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 0.00