Is there a relationship between kisspeptin, oxidative stress, and polycystic ovary syndrome?

Aim: The etiology of PCOS is primarily accepted as an ovarian disorder, and many mechanisms and theories have been proposed regarding the causes of this disease picture.It is thought that the relationship between kisspeptin and the hypothalamic-pituitary-gonadal axis may be related to changes in GnRH secretion in patients with PCOS.Materials and Methods: In our study, 37 patients with newly diagnosed Polycystic Ovary Syndrome and 38 healthy control groups were analyzed.Result: No significant difference was found between kisspeptin, glutathione peroxidase, and superoxide dismutase levels in the patient and control groups.However, the mean catalase level was found to be significantly lower in the PCOS group compared to the control group (285.73 26.10 vs. 382.30 39.76, p<0.05).No significant correlation was observed between kisspeptin and HOMA, free testosterone, and DHEA-S levels in our PCOS group.However, catalase levels were observed to be statistically significantly correlated with kisspeptin (r=0.340,p<0.05).Discussion: It is obvious that new studies are needed to evaluate PCOS phenotypes and subgroups in a larger series in order to understand the real role of kisspeptin in PCOS pathophysiology and to analyze its metabolic relationships.