Synergistic isoniazid-Mn( <scp>ii</scp> ) mediated non-Fenton-type hydroxyl radical generation for amplifying tumor chemodynamic therapy
An intelligent INH@ZIF@MnO<sub>2</sub>/HA nanotherapeutic platform, ingeniously engineered to augment tumor-specific oxidative stress in chemodynamic therapy, effectively harnesses the isoniazid (INH)-mediated generation of highly reactive non-Fenton-type hydroxyl radicals (˙OH) catalyzed by Mn<sup>2+</sup> ions.
Authors
- Shajun Zhu
- Miao Yan
- Xufeng Liang (ORCID: https://orcid.org/0000-0001-6042-484X)
- Yang Wang (ORCID: https://orcid.org/0000-0003-4239-8566)
- Tingting Chen (ORCID: https://orcid.org/0000-0002-5022-4243)
- Jin Wang (ORCID: https://orcid.org/0000-0003-4957-5553)
- Jian An (ORCID: https://orcid.org/0000-0001-7717-8382)
- Yan Cai
- Yong Yao (ORCID: https://orcid.org/0000-0001-5566-4822)
- Biling Su
Institutions
- Nantong University (CN)
- Affiliated Hospital of Nantong University (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc03099d
- Citations
- 1
- Primary Topic
- Lanthanide and Transition Metal Complexes
- Type
- article
- Field-Weighted Citation Impact
- 0.52
Funders
- Natural Science Foundation of Nantong City
- Graduate Research and Innovation Projects of Jiangsu Province